Pregnenolone

Pregnenolone is often referred to as the “mother hormone” since it is the first hormone at the top of the cascade that makes progesterone, cortisol, DHEA, testosterone and all estrogens. It’s role in the adrenal-cortisol pathway includes supporting a wide range of functions including memory, cognition, immune function, joints and energy.*

Pregnenolone belongs to a group of neurosteroids (like DHEA, DHEA-S, and progesterone) that are in high concentrations in certain areas of the brain. These protect the nerve cells and enhance myelination. Pregnenolone is lipophilic and crosses the blood-brain barrier to support memory and cognition.*

In clinical practice, when serum pregnenolone levels are in the lowest quartile before 8 AM, consideration should be given to full adrenal support which includes:

• reducing physical and mental stressors,

• supplementation with pregnenolone 50-100 mg,

• optimizing all hormones including thyroid,

• assessing nutrient status and

• detoxifying with 100 ounces of mineralized water